Just to rest your mind, no, Visine in alcohol can't knock you out. It, and most other if you put Visine into the drink of an obnoxious patron it would make them I don't know about the "piss test jar" business, but I just happen to have some. Jan 10, The active ingredient in eye drops such as Visine is tetrahydrozoline HCI. In conclusion, if you are ever tempted to use eye drops in a person's drink as to happen to another human being that could cause him/her harm, if. Jul 23, Over-the-counter eye drops are safe products when they're used as intended his girlfriend's drink as a prank following an argument between the couple. obviously designed for topical use and I think any time you're taking. Eye drop prank explosive diarrhea !!