If you wake up with a headache after a night of overindulging, sometimes figuring out what painkiller to take can make the headache even worse. Taking. Jul 29, This second interaction is what can happen when you mix ibuprofen and If you drink while taking ibuprofen, you definitely should not drive. Jun 22, Pain relievers like Advil (ibuprofen) and Tylenol (acetaminophen) can have some dicey effects when mixed with alcohol. Can You Drink Alcohol While Taking Ibuprofen? Jan 11, Can you drink alcohol with ibuprofen? — Sharon, Georgia. While it is generally safe to take ibuprofen and drink alcohol, it is highly. Do not drink alcohol if you're taking some types of painkillers (analgesics), such as paracetamol or ibuprofen; providing you get relevant advice (as described. Aug 5, If you drink while taking ibuprofen, you should not drive. Long-term use of ibuprofen can also damage the kidneys. The use of alcohol can damage the kidneys.